| Biography | |
|---|---|
 Prof. M. Michael Gromiha Indian Institute of Technology (IIT) Madras, India |
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| Title: Bioinformatics approaches for understanding the binding affinity of protein-protein complexes and their mutants | |
| Abstract:
Protein-protein interactions play crucial roles in many biological processes and responsible for smooth functioning of the machinery in living organisms. Predicting the binding affinity of protein-protein complexes and understanding the recognition mechanism are challenging problems in computational and molecular biology (1,2). Using a generalized energy based approach we showed that charged and aromatic residues are important for binding in protein-protein complexes. These residues influence to form cation–, electrostatic and aromatic interactions. Our observations have been verified with the experimental binding specificity of protein-protein complexes and found good agreement with experiments (3). Further, we have developed algorithms for discriminating protein-protein complexes based on their binding affinities (4), predicting the binding affinity (5) and constructing protein-protein interaction networks (6). We have also analyzed the integrative role of amino acid residues involved in both stability and binding (7). Recently, we developed a database for binding affinity of protein-protein complexes and their mutants (8). Utilizing the database, we analyzed the factors influencing the affinity of single mutants, the additivity effects of double mutants (9) and developed a method for predicting the binding affinity change upon mutation (10). The salient features of the results will be discussed.
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| Biography: M. Michael Gromiha received his PhD in physics from Bharathidasan University, India, and served as a post-doctoral fellow, STA fellow, RIKEN researcher, Research scientist, and Senior scientist at the International Center for Genetic Engineering and Biotechnology (ICGEB), Italy, The Institute of Physical and Chemical Research (RIKEN), Japan and the Institute of Advanced Industrial Science and Technology (AIST), Japan till 2010. Currently, he is working as a Professor at the Indian Institute of Technology (IIT) Madras, India. His main research interests include sequence and structural analysis, prediction, folding, and stability of globular and membrane proteins, protein-protein, protein-nucleic acid and protein-ligand interactions, development of bioinformatics databases and tools, structure based drug design and next generation sequence analysis. He has published more than 220 research articles, 40 reviews, seven editorials, and two books entitled “Protein Bioinformatics: From Sequence to Function” by Elsevier/Academic Press and “Protein Interactions: Computational methods, analysis and prediction” by World Scientific. His papers received more than 10,000 citations and his h-index is 55. He is an Associate Editor of BMC Bioinformatics, Section Editor of Current Protein and Peptide Science as well as an Editorial board member of Scientific Reports, Biology Direct, Journal of Bioinformatics and Computational Biology, Genes and Current Computer Aided Drug Design. He has delivered several plenary/keynote/invited talks in international/national conferences/symposia and reputed institutions. He has received several awards including the Oxford University Press Bioinformatics prize, Okawa Science Foundation Research Grant, Young Scientist Travel awards from ISCB, JSPS, AMBO and ICTP, Best Paper Award at ICIC2011, ICTP Associateship Award, ICMR International Fellowship for Senior Biomedical Scientists, INSA Senior Scientist Award, Best Paper Award in Bioinformatics by the Department of Biotechnology, India, Institute Research and Development Award from IIT Madras, Outstanding Performance Award from Initiative for Parallel Bioinformatics (IPAB), Tokyo Institute of Technology, Japan and Tamilnadu Scientist Award (TANSA) from Tamilnadu State Council for Science and Technology, India. | |
