| Biography | |
|---|---|
 Prof. Kiyoshi NOKIHARA HiPep Laboratories, Japan |
|
| Title: Gastric pre-cancer diagnostics by the novel bio-detection system, PepTenChip®, followed by statistical analyses, not depending on disease-related marker molecules | |
| Abstract:
The novel bio-detection system, designated PepTenChip® uses labelled structured peptides as capturing molecules. Recognition by designed peptide-library immobilized on a novel chip (made from amorphous carbon) generates fluorescent intensity changes with and without analytes, which can be converted into bar-coded, protein fingerprints[1,2]. Using this unique system L-type atypical BSE was successfully differentiated from classical BSE and scrapie[3]. Recently four basic key technologies for bio-detection have been successfully completed: peptide libraries for capture molecules, novel chip material with optimized surface chemistry, a high throughput arraying technology and construction of a small portable detector (PepTenCam). We applied this technology to rapidly and objectively determine and differentiate gastric pre-cancer states. PepTenChip® can play powerful diagnostic tools and provide an objective indicator not depending on clinician’s skill. PepTenChip® may realize health care of heavy diseases/elderly peoples, who cannot explain their problems to their doctors. The present novel PepTenCam is not only for clinical use but can be also applied in field and home-medical care settings.
| |
| Biography: Dr. Nokihara initially studied in Tokyo, followed by many years of academic research mainly in Germany. 1974-78 Researcher, DW-Institut (Insulin Research Group), Technischen Hochschule Aachen, Germany. 1979 Application Manager of Finnegan Institute, Silicon Valley, CA, USA. 1980-1985 Assistant Professor of the Faculty of Pharmaceutical Sciences, Shizuoka Prefectural University, Japan. 1985-87 invited to the Faculty of Medicine, University of Heidelberg in the role of a visiting Professor, granted by the Alexander von Humboldt Foundation, Germany. 1987-90 Researcher, in German National Institute for Biotechnological Research 1990-2002 invited as a Manager and Chief of R&D, Head of the Life Science Center, Shimadzu Corporation. In addition to his business commitments in Shimadzu Corp. academic positions as Visiting Professors, Tokyo University of Agriculture and Technology, and Tokyo Metropolitan Institute for Neuroscience Research (1992-2002), 2002-present: a visiting Professor of Nanjing Medical University (China) to continue academic research and teaching activities. 2002 Founded independently HiPep Laboratories, since then, Nokihara managed several national projects as a leader and received many grants. By the results of his research he received several prizes and awards. 2017-present invited as the first foreign Professor at the 1st School of Clinical Medicine, Nanjing Medical University, China. Dr. Nokihara has ca 300 scientific publications and over 130 patent applications. Proficiency (wide and interdisciplinary fields): Peptide & Protein Science: Chemistry, Biology, Bio-physics, Structural Biology, Molecular design, Immunology, Endocrinology, Instrumentation, Bio-analyses, Biodetection Technologies, Combinatorial Chemistry, Drug Discovery | |
